sackler school

Exercise-induced hormone irisin linked to new mechanisms for bone metabolism

BOSTON (March 3, 2017)—Two weeks of voluntary wheel running induces higher expression of irisin—a fat-burning hormone that is released during exercise—in bone tissue in mice. In addition, systemic administration of irisin increased bone formation and thickness, mimicking the effects of exercise on the mouse skeletal system. The findings demonstrate a potential new mechanism for the regulation of bone metabolism.

The study was led by scientists from Tufts University School of Dental Medicine (TUSDM) and published in Bone Research.