Postpartum Depression Spans Generations

Animal study suggests stress-induced depression in new mothers extends to daughters
October 8, 2013

For More Information or to Request a Photo from this News Release, Contact:

Rushmie Nofsinger

Share

 NORTH GRAFTON, Mass. (October 8, 2013) – A recently published study suggests that exposure to social stress not only  impairs a mother’s ability to care for her children but can also negatively impact her daughter’s ability to provide maternal care to future offspring.

 Researchers at the Cummings School of Veterinary Medicine at Tufts University conducted a transgenerational study with female rats, examining the behavioral and physiological changes in mothers exposed to chronic social stress early in life as a model for postpartum depression and anxiety.

A different male rat was placed in the cage of the first-generation mothers and their newly born pups for an hour a day for 15 days. Consistent with previous research, the lactating mother rats responded to the stress of the intruder with depressed maternal care, impaired lactation, and increased anxiety.  The pups of these mothers were also exposed to the conflict between their mothers and the male intruders.

After reaching maturation, second-generation females were mated and compared to a control group where neither the mother nor the pups had been exposed to a male intruder. The second generation mothers that experienced the early life stress also displayed depressed maternal care, impaired lactation, and increased anxiety. There were also changes to hormone levels: an increase in the stress hormone corticosterone, and decreases in oxytocin, prolactin (important to both maternal behavior and lactation) and estradiol.

“The endocrine and behavioral data are consistent with what has been reported in studies of depressed human mothers. The potential with this animal model is that it can be used to study new preventive measures and treatments for postpartum depression and anxiety, and the adverse effects of these disorders on offspring,” said Benjamin C. Nephew, Ph.D., assistant professor in the Department of Biomedical Sciences at TCSVM and principal investigator of the study. Nephew is also a faculty member of the neuroscience program at the Sackler School of Graduate Biomedical Sciences at Tufts.

The study was published in the September issue of Hormones and Behavior.

“The chronic social stress model used in this study provides insight into how social stress affects both human and animal behavior in the areas of maternal care, anxiety and lactation, and provides a wealth of observations,” said Lindsay M. Carini, the study’s lead author.

This work was supported by the National Institute of Child Health and Human Development under award number R00 HD059943, the National Center for Research Resources under award number UL1 RR025752, and the National Center for Advancing Translational Sciences, National Institutes of Health, under award number UL1 TR000073e.

This work builds off earlier Tufts research in the area of reproductive biology, which includes initial findings on the effects of chronic social stress on maternal behavior which was published in Stress by Nephew and Professor of Biomedical Sciences Robert Bridges, Nephew’s postdoctoral mentor at TCSVM.

Carini, Lindsay M., Nephew, Benjamin C., Effects of early life social stress on endocrinology, maternal behavior, and lactation in rats, Hormones and Behavior (2013), doi: 10.1016/j.yhbeh.2013.08.011.

###

About the Cummings School of Veterinary Medicine at Tufts University

Founded in 1978 in North Grafton, Mass., Cummings School of Veterinary Medicine at Tufts University is internationally esteemed for academic programs that impact society and the practice of veterinary medicine; three hospitals and four clinics that combined log more than 80,000 animal cases each year; and groundbreaking research that benefits animal, public, and environmental health.